Cyclin-dependent kinase 8/19 · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P49336. Use UniProt P49336 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P49336 as the stable identity anchor, then attach disease evidence before program review.
Cyclin-dependent kinase 8
Review this target as Cyclin-dependent kinase 8/19, mapped to UniProt P49336. ChEMBL maps the protein component as Cyclin-dependent kinase 8. Sequence length is 464 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cyclin-dependent kinase 8/19 as ChEMBL target CHEMBL3885556, mapped to UniProt P49336. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cyclin-dependent kinase 8/19 |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | P49336 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cyclin-dependent kinase 8 |
| UniProt Accession | P49336 |
| Component Type | Protein |
| Sequence Length | 464 aa |
Cyclin-dependent kinase 8
Review this target as Cyclin-dependent kinase 8/19, mapped to UniProt P49336. ChEMBL maps the protein component as Cyclin-dependent kinase 8. Sequence length is 464 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3799396 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL3798726 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL3798611 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL3797571 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3799212 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL3799307 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL3799592 | 8.74 | IC50 | 1.8 | Preclinical |
| CHEMBL3800105 | 8.68 | IC50 | 2.1 | Preclinical |
| CHEMBL3800080 | 8.62 | IC50 | 2.4 | Preclinical |
| CHEMBL3799824 | 8.54 | IC50 | 2.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 8 | 66 | 7.7 |
| tissue-based format | 7 | 2 | 7.3 |
| subcellular format | 4 | 0 | — |
| assay format | 1 | 11 | 6.4 |