Compound Detail
CHEMBL3800105
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Cn1cc(-c2ccc(-c3cnc(N)c(C(F)(F)F)c3N3CCC4(CCNC4=O)CC3)cc2)cn1
Basic Information
| ChEMBL ID | CHEMBL3800105 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NAVWVDFKHIIIDK-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
3
PK Parameters
4
Publications
0
Known Names
Molecular Properties
470.5
MW (Da)
3.86
ALogP
6
HBA
2
HBD
89.1
PSA (Ų)
0.61
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cyclin-dependent kinase 8/19 CHEMBL3885556 | IC50 | 8.68 | 8.68 | 2.1 | 1 |
| Cyclin-dependent kinase 8 CHEMBL5719 | IC50 | 8.03 | 8.03 | 9.3 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 128.0 | mL.min-1.g-1 | Mus musculus |
| CL | 55.0 | mL.min-1.g-1 | Rattus norvegicus |
| CL | 35.0 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 8/19 | IC50 | = | 2.1 | nM | 8.68 | Binding affinity to CDK8/CDK19 in human 7dF3 cells preincubated for 2 hrs follow... | 26796641 |
| Cyclin-dependent kinase 8 | IC50 | = | 9.3 | nM | 8.03 | Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based... | 26796641 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26796641 | 10.1021/acs.jmedchem.5b01685 | ADMET | 3 |
| 26796641 | 10.1021/acs.jmedchem.5b01685 | Cyclin-dependent kinase 8 | 1 |
| 26796641 | 10.1021/acs.jmedchem.5b01685 | Cyclin-C/Cyclin-dependent kinase 19 | 1 |
| 26796641 | 10.1021/acs.jmedchem.5b01685 | Cyclin-dependent kinase 8/19 | 1 |
Data from ChEMBL 36 via Core Engine