Compound Detail
CHEMBL3798726
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3798726 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RDVHTWWUICGUOA-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
3
PK Parameters
4
Publications
0
Known Names
Molecular Properties
480.5
MW (Da)
3.15
ALogP
5
HBA
1
HBD
82.6
PSA (Ų)
0.71
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cyclin-dependent kinase 8/19 CHEMBL3885556 | IC50 | 9.22 | 9.22 | 0.6 | 1 |
| Cyclin-C/Cyclin-dependent kinase 19 CHEMBL3883323 | IC50 | 8.72 | 8.72 | 1.9 | 1 |
| Cyclin-dependent kinase 8 CHEMBL5719 | IC50 | 8.48 | 8.48 | 3.3 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 1000.0 | mL.min-1.g-1 | Mus musculus |
| CL | 110.0 | mL.min-1.g-1 | Rattus norvegicus |
| CL | 102.0 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 8/19 | IC50 | = | 0.6 | nM | 9.22 | Binding affinity to CDK8/CDK19 in human 7dF3 cells preincubated for 2 hrs follow... | 26796641 |
| Cyclin-C/Cyclin-dependent kinase 19 | IC50 | = | 1.9 | nM | 8.72 | Binding affinity to human CDK19 (1 to 502 amino acid residues)/Cyclin C (1 to 28... | 26796641 |
| Cyclin-dependent kinase 8 | IC50 | = | 3.3 | nM | 8.48 | Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based... | 26796641 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26796641 | 10.1021/acs.jmedchem.5b01685 | ADMET | 3 |
| 26796641 | 10.1021/acs.jmedchem.5b01685 | Cyclin-dependent kinase 8 | 1 |
| 26796641 | 10.1021/acs.jmedchem.5b01685 | Cyclin-C/Cyclin-dependent kinase 19 | 1 |
| 26796641 | 10.1021/acs.jmedchem.5b01685 | Cyclin-dependent kinase 8/19 | 1 |
Data from ChEMBL 36 via Core Engine