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Assay Detail

CHEMBL4808052

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HIPK4 (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Homeodomain-interacting protein kinase 4 (CHEMBL1075167)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Hipk inhibitors and methods of use thereof
(2020)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 8.03 8.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4855209 1 8.55
CHEMBL1336 SORAFENIB 4.0 1 8.52
CHEMBL4859179 1 8.48
CHEMBL4850066 1 8.29
CHEMBL4855979 1 8.28
CHEMBL4870763 1 8.02
CHEMBL4874174 1 7.72
CHEMBL4847460 1 7.64
CHEMBL4875968 1 7.50
CHEMBL4853006 1 7.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4855209 IC50 = 2.8 nM 8.55
CHEMBL1336 SORAFENIB IC50 = 3.0 nM 8.52
CHEMBL4859179 IC50 = 3.3 nM 8.48
CHEMBL4850066 IC50 = 5.1 nM 8.29
CHEMBL4855979 IC50 = 5.2 nM 8.28
CHEMBL4870763 IC50 = 9.6 nM 8.02
CHEMBL4874174 IC50 = 19.0 nM 7.72
CHEMBL4847460 IC50 = 23.0 nM 7.64
CHEMBL4875968 IC50 = 32.0 nM 7.50
CHEMBL4853006 IC50 = 49.0 nM 7.31