Assay Detail
Binding
CHEMBL4808635
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPARgamma expressed in CHO cells assessed as increase in receptor transcriptional activity incubated for 24 hrs by dual luciferase reporter gene assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Activity Relationship Study and Biological Evaluation of 2-(Disubstituted phenyl)-indole-5-propanoic Acid Derivatives as GPR40 Full Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 4.41 | 4.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854804 | — | — | 1 | 4.56 |
| CHEMBL4859651 | — | — | 1 | 4.25 |
| CHEMBL4866406 | — | — | 1 | - |
| CHEMBL4852222 | — | — | 1 | - |
| CHEMBL4869870 | — | — | 1 | - |
| CHEMBL4866568 | — | — | 1 | - |
| CHEMBL4852865 | — | — | 1 | - |
| CHEMBL4848974 | — | — | 1 | - |
| CHEMBL4858086 | — | — | 1 | - |
| CHEMBL4855306 | — | — | 1 | - |
| CHEMBL4877893 | — | — | 1 | - |
| CHEMBL4868676 | — | — | 1 | - |
| CHEMBL4859407 | — | — | 1 | - |
| CHEMBL4847662 | — | — | 1 | - |
| CHEMBL4872298 | — | — | 1 | - |
| CHEMBL4865460 | — | — | 1 | - |
| CHEMBL4850966 | — | — | 1 | - |
| CHEMBL4857550 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854804 | — | EC50 | = | 27770.0 | nM | 4.56 |
| CHEMBL4859651 | — | EC50 | = | 56940.0 | nM | 4.25 |
| CHEMBL4866406 | — | EC50 | - | — | - | |
| CHEMBL4852222 | — | EC50 | - | — | - | |
| CHEMBL4869870 | — | EC50 | - | — | - | |
| CHEMBL4866568 | — | EC50 | - | — | - | |
| CHEMBL4852865 | — | EC50 | - | — | - | |
| CHEMBL4848974 | — | EC50 | - | — | - | |
| CHEMBL4858086 | — | EC50 | - | — | - | |
| CHEMBL4855306 | — | EC50 | - | — | - | |
| CHEMBL4877893 | — | EC50 | - | — | - | |
| CHEMBL4868676 | — | EC50 | - | — | - | |
| CHEMBL4859407 | — | EC50 | - | — | - | |
| CHEMBL4847662 | — | EC50 | - | — | - | |
| CHEMBL4872298 | — | EC50 | - | — | - | |
| CHEMBL4865460 | — | EC50 | - | — | - | |
| CHEMBL4850966 | — | EC50 | - | — | - | |
| CHEMBL4857550 | — | EC50 | - | — | - |