Assay Detail
Functional
CHEMBL4808944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 5-(3-Chlorophenylamino)benzo[<i>c</i>][2,6]naphthyridine Derivatives as Highly Selective CK2 Inhibitors with Potent Cancer Cell Stemness Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.98 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4860630 | — | — | 1 | 5.51 |
| CHEMBL4848224 | — | — | 1 | 5.37 |
| CHEMBL4870899 | — | — | 1 | 5.34 |
| CHEMBL4867054 | — | — | 1 | 5.23 |
| CHEMBL4849246 | — | — | 1 | 5.16 |
| CHEMBL4878998 | — | — | 1 | 5.14 |
| CHEMBL4872225 | — | — | 1 | 5.12 |
| CHEMBL4862003 | — | — | 1 | 5.10 |
| CHEMBL4875815 | — | — | 1 | 5.09 |
| CHEMBL4845902 | — | — | 1 | 5.07 |
| CHEMBL4855171 | — | — | 1 | 5.06 |
| CHEMBL4865194 | — | — | 1 | 5.06 |
| CHEMBL4870230 | — | — | 1 | 5.01 |
| CHEMBL4875513 | — | — | 1 | 4.96 |
| CHEMBL4852239 | — | — | 1 | 4.89 |
| CHEMBL4854640 | — | — | 1 | 4.88 |
| CHEMBL1230165 | SILMITASERTIB | 2.0 | 1 | 4.88 |
| CHEMBL4873444 | — | — | 1 | 4.86 |
| CHEMBL4866502 | — | — | 1 | 4.80 |
| CHEMBL4846022 | — | — | 1 | 4.78 |
| CHEMBL4848072 | — | — | 1 | 4.75 |
| CHEMBL4857107 | — | — | 1 | 4.68 |
| CHEMBL4848229 | — | — | 1 | 4.67 |
| CHEMBL4850291 | — | — | 1 | 4.61 |
| CHEMBL4857079 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4860630 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL4848224 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL4870899 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4867054 | — | IC50 | = | 5910.0 | nM | 5.23 |
| CHEMBL4849246 | — | IC50 | = | 6910.0 | nM | 5.16 |
| CHEMBL4878998 | — | IC50 | = | 7260.0 | nM | 5.14 |
| CHEMBL4872225 | — | IC50 | = | 7520.0 | nM | 5.12 |
| CHEMBL4862003 | — | IC50 | = | 7980.0 | nM | 5.10 |
| CHEMBL4875815 | — | IC50 | = | 8130.0 | nM | 5.09 |
| CHEMBL4845902 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4855171 | — | IC50 | = | 8620.0 | nM | 5.06 |
| CHEMBL4865194 | — | IC50 | = | 8790.0 | nM | 5.06 |
| CHEMBL4870230 | — | IC50 | = | 9710.0 | nM | 5.01 |
| CHEMBL4875513 | — | IC50 | = | 10910.0 | nM | 4.96 |
| CHEMBL4852239 | — | IC50 | = | 12760.0 | nM | 4.89 |
| CHEMBL4854640 | — | IC50 | = | 13250.0 | nM | 4.88 |
| CHEMBL1230165 | SILMITASERTIB | IC50 | = | 13210.0 | nM | 4.88 |
| CHEMBL4873444 | — | IC50 | = | 13680.0 | nM | 4.86 |
| CHEMBL4866502 | — | IC50 | = | 15920.0 | nM | 4.80 |
| CHEMBL4846022 | — | IC50 | = | 16540.0 | nM | 4.78 |
| CHEMBL4848072 | — | IC50 | = | 17730.0 | nM | 4.75 |
| CHEMBL4857107 | — | IC50 | = | 20830.0 | nM | 4.68 |
| CHEMBL4848229 | — | IC50 | = | 21210.0 | nM | 4.67 |
| CHEMBL4850291 | — | IC50 | = | 24770.0 | nM | 4.61 |
| CHEMBL4857079 | — | IC50 | = | 28110.0 | nM | 4.55 |