Assay Detail
Binding
CHEMBL4809560
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Inhibition of BRD4 (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of BET inhibitors as potential treatments for cancer: A search for structural diversity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.78 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4846895 | — | — | 1 | 9.22 |
| CHEMBL4859923 | — | — | 1 | 9.05 |
| CHEMBL4848871 | — | — | 1 | 9.05 |
| CHEMBL4864173 | — | — | 1 | 9.00 |
| CHEMBL4863199 | — | — | 1 | 8.92 |
| CHEMBL4869203 | — | — | 1 | 8.85 |
| CHEMBL4857742 | — | — | 1 | 8.80 |
| CHEMBL4875203 | — | — | 1 | 8.70 |
| CHEMBL4871769 | — | — | 1 | 8.64 |
| CHEMBL4850311 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4846895 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4859923 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4848871 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4864173 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4863199 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4869203 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4857742 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4875203 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4871769 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4850311 | — | IC50 | = | 27.0 | nM | 7.57 |