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Assay Detail

CHEMBL4809629

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of self-induced amyloid beta(1 to 42) (unknown origin) aggregation by thioflavin-T fluorescence assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amyloid-beta precursor protein (CHEMBL2487)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis and biological evaluation of novel deoxyvasicinone-indole as multi-target agents for Alzheimer's disease.
Nerella A, Jeripothula M.
Bioorg Med Chem Lett (2021) 49 : 128212 -128212
PubMed 34153471 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.53 5.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4861956 1 5.92
CHEMBL4854341 1 5.81
CHEMBL4878452 1 5.79
CHEMBL4871461 1 5.77
CHEMBL4874567 1 5.67
CHEMBL4871713 1 5.64
CHEMBL4853181 1 5.51
CHEMBL4864253 1 5.49
CHEMBL4856921 1 5.49
CHEMBL4854859 1 5.29
CHEMBL4870177 1 5.28
CHEMBL4861631 1 5.21
CHEMBL497 CLIOQUINOL 4.0 1 5.01
CHEMBL456881 DEOXYVASICINONE 1 -
CHEMBL95 TACRINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4861956 IC50 = 1210.0 nM 5.92
CHEMBL4854341 IC50 = 1560.0 nM 5.81
CHEMBL4878452 IC50 = 1620.0 nM 5.79
CHEMBL4871461 IC50 = 1690.0 nM 5.77
CHEMBL4874567 IC50 = 2160.0 nM 5.67
CHEMBL4871713 IC50 = 2300.0 nM 5.64
CHEMBL4853181 IC50 = 3090.0 nM 5.51
CHEMBL4864253 IC50 = 3260.0 nM 5.49
CHEMBL4856921 IC50 = 3270.0 nM 5.49
CHEMBL4854859 IC50 = 5100.0 nM 5.29
CHEMBL4870177 IC50 = 5270.0 nM 5.28
CHEMBL4861631 IC50 = 6100.0 nM 5.21
CHEMBL497 CLIOQUINOL IC50 = 9800.0 nM 5.01
CHEMBL456881 DEOXYVASICINONE IC50 - -
CHEMBL95 TACRINE IC50 - -