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Assay Detail

CHEMBL4809876

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MDA-MB-231 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Autocuration

Target

MDA-MB-231 (CHEMBL400)
Type CELL-LINE
Organism Homo sapiens

Publication

Cyclopentenone-Containing Tetrahydroquinoline and Geldanamycin Alkaloids from <i>Streptomyces malaysiensis</i> as Potential Anti-Androgens against Prostate Cancer Cells.
Xie Y, Guo L, Huang J, Huang X, Cong Z, Liu Q, Wang Q, Pang X, Xiang S, Zhou X, Liu Y, Wang J, Wang J.
J Nat Prod (2021) 84 : 2004 -2011
PubMed 34225450 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 5.52 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4851816 1 6.70
CHEMBL278315 GELDANAMYCIN 2.0 1 5.72
CHEMBL4853217 1 5.28
CHEMBL4846650 1 5.14
CHEMBL394931 1 4.77
CHEMBL4865631 1 -
CHEMBL404493 1 -
CHEMBL4857765 1 -
CHEMBL4849788 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4851816 IC50 = 200.0 nM 6.70
CHEMBL278315 GELDANAMYCIN IC50 = 1900.0 nM 5.72
CHEMBL4853217 IC50 = 5200.0 nM 5.28
CHEMBL4846650 IC50 = 7200.0 nM 5.14
CHEMBL394931 IC50 = 17000.0 nM 4.77
CHEMBL4865631 IC50 > 40000.0 nM -
CHEMBL404493 IC50 > 40000.0 nM -
CHEMBL4857765 IC50 > 40000.0 nM -
CHEMBL4849788 IC50 > 40000.0 nM -