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Assay Detail

CHEMBL4809880

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Functional
Cytotoxicity against human C42B cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LNCaP C4-2B
Confidence 1 — Organism
Curated By Autocuration

Target

LNCaP C4-2B (CHEMBL4296461)
Type CELL-LINE
Organism Homo sapiens

Publication

Cyclopentenone-Containing Tetrahydroquinoline and Geldanamycin Alkaloids from <i>Streptomyces malaysiensis</i> as Potential Anti-Androgens against Prostate Cancer Cells.
Xie Y, Guo L, Huang J, Huang X, Cong Z, Liu Q, Wang Q, Pang X, Xiang S, Zhou X, Liu Y, Wang J, Wang J.
J Nat Prod (2021) 84 : 2004 -2011
PubMed 34225450 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.32 7.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4851816 1 7.17
CHEMBL278315 GELDANAMYCIN 2.0 1 6.30
CHEMBL4853217 1 5.44
CHEMBL394931 1 4.96
CHEMBL4846650 1 4.85
CHEMBL1082407 ENZALUTAMIDE 4.0 1 4.75
CHEMBL4849788 1 4.60
CHEMBL404493 1 4.50
CHEMBL4865631 1 -
CHEMBL4857765 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4851816 IC50 = 67.0 nM 7.17
CHEMBL278315 GELDANAMYCIN IC50 = 500.0 nM 6.30
CHEMBL4853217 IC50 = 3600.0 nM 5.44
CHEMBL394931 IC50 = 11000.0 nM 4.96
CHEMBL4846650 IC50 = 14000.0 nM 4.85
CHEMBL1082407 ENZALUTAMIDE IC50 = 18000.0 nM 4.75
CHEMBL4849788 IC50 = 25000.0 nM 4.60
CHEMBL404493 IC50 = 32000.0 nM 4.50
CHEMBL4865631 IC50 > 40000.0 nM -
CHEMBL4857765 IC50 > 40000.0 nM -