Assay Detail
Functional
CHEMBL4809912
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Inhibition of LPS-induced MCP1 production in human whole blood preincubated for 30 mins followed by LPS addition measured after 24 hrs by immunoassay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of a Series of <i>N</i>-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.68 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4846199 | — | — | 1 | 7.00 |
| CHEMBL4873182 | — | — | 1 | 7.00 |
| CHEMBL4867556 | — | — | 1 | 6.90 |
| CHEMBL4862372 | — | — | 1 | 6.80 |
| CHEMBL4863388 | — | — | 1 | 6.70 |
| CHEMBL4854638 | — | — | 1 | 6.70 |
| CHEMBL4861542 | — | — | 1 | 6.60 |
| CHEMBL4868170 | — | — | 1 | 6.60 |
| CHEMBL4849259 | — | — | 1 | 6.50 |
| CHEMBL4857098 | — | — | 1 | 6.50 |
| CHEMBL4871681 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4846199 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4873182 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4867556 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL4862372 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4863388 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4854638 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4861542 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4868170 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4849259 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4857098 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4871681 | — | IC50 | = | 630.96 | nM | 6.20 |