Assay Detail
Binding
CHEMBL4810081
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human NNMT expressed in HEK293 cells assessed as reduction in 1-methyl-nicotinamide formation measured after 24 hrs by RapidFire Mass spectroscopy
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.77 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4872872 | — | — | 1 | 6.11 |
| CHEMBL4859806 | — | — | 1 | 5.43 |
| CHEMBL4868588 | — | — | 1 | - |
| CHEMBL4867273 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4872872 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4859806 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4868588 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4867273 | — | IC50 | > | 100000.0 | nM | - |