Assay Detail
Functional
CHEMBL4810141
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Antiproliferative activity against human NCI-H1581 cells assessed as inhibition of cell proliferation incubated for 3 days by Cell Titer Aqueous96 one solution reagent assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1581 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.85 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870179 | — | — | 1 | 8.89 |
| CHEMBL4862823 | — | — | 1 | 8.68 |
| CHEMBL4863146 | — | — | 1 | 8.33 |
| CHEMBL4863224 | — | — | 1 | 8.26 |
| CHEMBL4846809 | — | — | 1 | 8.15 |
| CHEMBL4847441 | — | — | 1 | 7.96 |
| CHEMBL4851637 | — | — | 1 | 7.75 |
| CHEMBL4856613 | — | — | 1 | 7.40 |
| CHEMBL4871046 | — | — | 1 | 7.35 |
| CHEMBL4874869 | — | — | 1 | 7.32 |
| CHEMBL4868291 | — | — | 1 | 6.27 |
| CHEMBL4866178 | — | — | 1 | - |
| CHEMBL4848530 | — | — | 1 | - |
| CHEMBL4858423 | — | — | 1 | - |
| CHEMBL4873003 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870179 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4862823 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4863146 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4863224 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4846809 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4847441 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4851637 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4856613 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4871046 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4874869 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4868291 | — | IC50 | = | 538.0 | nM | 6.27 |
| CHEMBL4866178 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL4848530 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL4858423 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL4873003 | — | IC50 | > | 200.0 | nM | - |