Assay Detail
ADMET
CHEMBL4810177
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-KIT (unknown origin) incubated for 90 mins in presence of ATP by HTRF assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.57 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4871581 | — | — | 1 | 8.41 |
| CHEMBL4870179 | — | — | 1 | 7.92 |
| CHEMBL4853979 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4871581 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4870179 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4853979 | — | IC50 | = | 407.0 | nM | 6.39 |