Assay Detail
ADMET
CHEMBL4810364
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Inhibition of COX1 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 1 hr in presence of 10% FBS by RapidFire High-Throughput Mass Spectrometry
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293-T-REx |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.69 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4868446 | — | — | 1 | 6.89 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.39 |
| CHEMBL4867038 | — | — | 1 | 6.29 |
| CHEMBL4851236 | — | — | 1 | 5.61 |
| CHEMBL4870684 | — | — | 1 | 5.11 |
| CHEMBL4865464 | — | — | 1 | 4.85 |
| CHEMBL4859571 | — | — | 1 | 4.66 |
| CHEMBL416146 | ETORICOXIB | 4.0 | 1 | - |
| CHEMBL49319 | — | — | 1 | - |
| CHEMBL4866615 | — | — | 1 | - |
| CHEMBL4848190 | — | — | 1 | - |
| CHEMBL4864897 | — | — | 1 | - |
| CHEMBL4866509 | — | — | 1 | - |
| CHEMBL4848265 | — | — | 1 | - |
| CHEMBL4862802 | — | — | 1 | - |
| CHEMBL4867405 | — | — | 1 | - |
| CHEMBL4856126 | — | — | 1 | - |
| CHEMBL4877517 | — | — | 1 | - |
| CHEMBL4879174 | — | — | 1 | - |
| CHEMBL4873184 | — | — | 1 | - |
| CHEMBL4870569 | — | — | 1 | - |
| CHEMBL4857474 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4868446 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL118 | CELECOXIB | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4867038 | — | IC50 | = | 511.0 | nM | 6.29 |
| CHEMBL4851236 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL4870684 | — | IC50 | = | 7690.0 | nM | 5.11 |
| CHEMBL4865464 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4859571 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL416146 | ETORICOXIB | IC50 | > | 50000.0 | nM | - |
| CHEMBL49319 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4866615 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4848190 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4864897 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4866509 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4848265 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4862802 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4867405 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4856126 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4877517 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4879174 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4873184 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4870569 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4857474 | — | IC50 | > | 50000.0 | nM | - |