Assay Detail
Functional
CHEMBL4810416
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vivo inhibition of COX2 in po dosed C57BL/6J mouse model of spontaneous GI-tract tumor Apc-min assessed as chemopreventive effect by measuring reduction in polyp area and relevant ileum exposures
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.76 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 8.49 |
| CHEMBL4859571 | — | — | 1 | 6.80 |
| CHEMBL4868446 | — | — | 1 | 6.13 |
| CHEMBL4862802 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4859571 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4868446 | — | IC50 | = | 741.8 | nM | 6.13 |
| CHEMBL4862802 | — | IC50 | = | 2384.0 | nM | 5.62 |