Assay Detail
Binding
CHEMBL4810445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full length human GRK7 using casein as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counting based radiometry assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.82 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4877302 | — | — | 1 | 8.19 |
| CHEMBL4854871 | — | — | 1 | 7.82 |
| CHEMBL4847703 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4877302 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4854871 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4847703 | — | IC50 | = | 36.0 | nM | 7.44 |