Assay Detail
Binding
CHEMBL4811511
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 30 mins by DTNB assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Schistosoma mansoni |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Thioredoxin glutathione reductase (CHEMBL6110) ↗| Type | SINGLE PROTEIN |
| Organism | Schistosoma mansoni |
Publication
Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.48 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1439384 | — | — | 1 | 7.22 |
| CHEMBL1486739 | — | — | 1 | 6.89 |
| CHEMBL4846043 | — | — | 1 | 6.85 |
| CHEMBL1428415 | — | — | 1 | 6.68 |
| CHEMBL4852477 | — | — | 1 | 6.48 |
| CHEMBL1337170 | — | — | 1 | 5.70 |
| CHEMBL4858362 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1439384 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1486739 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4846043 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1428415 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4852477 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1337170 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL4858362 | — | IC50 | = | 2840.0 | nM | 5.55 |