Assay Detail
Binding
CHEMBL4811565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ALDH1A2 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.56 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4849586 | — | — | 1 | 7.68 |
| CHEMBL4876602 | — | — | 1 | 7.40 |
| CHEMBL4846203 | — | — | 1 | 7.24 |
| CHEMBL4875157 | — | — | 1 | 7.20 |
| CHEMBL4847114 | — | — | 1 | 7.19 |
| CHEMBL4859904 | — | — | 1 | 7.10 |
| CHEMBL4855442 | — | — | 1 | 7.05 |
| CHEMBL4848831 | — | — | 1 | 7.00 |
| CHEMBL4846491 | — | — | 1 | 6.97 |
| CHEMBL4848258 | — | — | 1 | 6.96 |
| CHEMBL4862833 | — | — | 1 | 6.96 |
| CHEMBL4861872 | — | — | 1 | 6.95 |
| CHEMBL4874309 | — | — | 1 | 6.87 |
| CHEMBL4213331 | — | — | 1 | 6.82 |
| CHEMBL4873090 | — | — | 1 | 6.77 |
| CHEMBL4876076 | — | — | 1 | 6.75 |
| CHEMBL4867380 | — | — | 1 | 6.67 |
| CHEMBL4873315 | — | — | 1 | 6.62 |
| CHEMBL4210115 | — | — | 1 | 6.60 |
| CHEMBL4868666 | — | — | 1 | 6.57 |
| CHEMBL4863668 | — | — | 1 | 6.52 |
| CHEMBL4849624 | — | — | 1 | 6.42 |
| CHEMBL4860590 | — | — | 1 | 6.40 |
| CHEMBL4848961 | — | — | 1 | 6.36 |
| CHEMBL4866017 | — | — | 1 | 6.22 |
| CHEMBL4877915 | — | — | 1 | 6.10 |
| CHEMBL4865571 | — | — | 1 | 6.09 |
| CHEMBL4849706 | — | — | 1 | 5.83 |
| CHEMBL4857551 | — | — | 1 | 5.80 |
| CHEMBL4846960 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4849586 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4876602 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4846203 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4875157 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4847114 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4859904 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4855442 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4848831 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4846491 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4848258 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4862833 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4861872 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4874309 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL4213331 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4873090 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4876076 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL4867380 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL4873315 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4210115 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4868666 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4863668 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4849624 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4860590 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4848961 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4866017 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4877915 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4865571 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4849706 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4857551 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4846960 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL4862831 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4874335 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4852411 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4855579 | — | IC50 | = | 3700.0 | nM | 5.43 |