Assay Detail
Binding
CHEMBL4812271
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MKK4 (unknown origin) by PanQinase assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity mitogen-activated protein kinase kinase 4 (CHEMBL2897) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.14 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4790247 | — | — | 1 | 7.54 |
| CHEMBL4784779 | — | — | 1 | 7.05 |
| CHEMBL4798975 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4790247 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4784779 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4798975 | — | IC50 | = | 146.0 | nM | 6.84 |