Assay Detail
Binding
CHEMBL4812828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-indued NF-kappaB activation in mouse RAW264.7 cells preincubated for 30 mins followed by LPS stimulation and measured after 10 hrs by luciferase assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tulipiferamide A, an Alkamide from <i>Liriodendron tulipifera</i>, Exhibits an Anti-Inflammatory Effect via Targeting IKKβ Phosphorylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.10 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257167 | — | — | 1 | 7.66 |
| CHEMBL485296 | EUPATOLIDE | — | 1 | 4.91 |
| CHEMBL4860231 | — | — | 1 | 4.85 |
| CHEMBL448297 | SAKURANETIN | — | 1 | 4.81 |
| CHEMBL510090 | LYSICAMINE | — | 1 | 4.75 |
| CHEMBL4876333 | — | — | 1 | 4.67 |
| CHEMBL4876121 | — | — | 1 | 4.61 |
| CHEMBL470879 | OXOPHOEBINE | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257167 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL485296 | EUPATOLIDE | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4860231 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL448297 | SAKURANETIN | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL510090 | LYSICAMINE | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL4876333 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL4876121 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL470879 | OXOPHOEBINE | IC50 | = | 28500.0 | nM | 4.54 |