Compound Detail
CHEMBL510090
LYSICAMINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL510090 |
| Name | LYSICAMINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DPBMWJXWUINLQT-UHFFFAOYSA-N |
7
Targets
7
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
291.3
MW (Da)
3.46
ALogP
4
HBA
0
HBD
48.4
PSA (Ų)
0.57
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 5.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAW264.7 CHEMBL612557 | IC50 | 5.19 | 5.19 | 6400.0 | 1 |
| WI-38 CHEMBL614391 | IC50 | 5.17 | 5.17 | 6700.0 | 1 |
| T-24 CHEMBL614774 | IC50 | 5.14 | 5.14 | 7300.0 | 1 |
| SK-OV-3 CHEMBL614925 | IC50 | 4.92 | 4.92 | 12100.0 | 1 |
| MGC-803 CHEMBL3706566 | IC50 | 4.8 | 4.8 | 15800.0 | 1 |
| Acetylcholinesterase CHEMBL4078 | IC50 | 4.79 | 4.79 | 16100.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.75 | 4.75 | 17800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAW264.7 | IC50 | = | 6400.0 | nM | 5.19 | Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induce... | 33939429 |
| WI-38 | IC50 | = | 6700.0 | nM | 5.17 | Antiproliferative activity against human WI-38 cells assessed as cell growth inh... | 35092899 |
| T-24 | IC50 | = | 7300.0 | nM | 5.14 | Antiproliferative activity against human T24 cells assessed as cell growth inhib... | 35092899 |
| SK-OV-3 | IC50 | = | 12100.0 | nM | 4.92 | Antiproliferative activity against human SK-OV-3 cells assessed as cell growth i... | 35092899 |
| MGC-803 | IC50 | = | 15800.0 | nM | 4.8 | Antiproliferative activity against human MGC-803 cells assessed as cell growth i... | 35092899 |
| Acetylcholinesterase | IC50 | = | 16100.0 | nM | 4.79 | Inhibition of electric eel AChE by Ellman's method | 20828184 |
| Unchecked | IC50 | = | 17800.0 | nM | 4.75 | Inhibition of LPS-indued NF-kappaB activation in mouse RAW264.7 cells preincubat... | 33939429 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23270663 | 10.1016/j.bmc.2012.11.038 | Unchecked | 4 |
| 9868142 | 10.1021/np9800046 | Platelet | 4 |
| 8158166 | 10.1021/np50103a009 | Saccharomyces cerevisiae | 4 |
| 20476748 | 10.1021/np100013r | Staphylococcus aureus | 3 |
| 9584402 | 10.1021/np970382v | Poliovirus 2 | 3 |
| 9584402 | 10.1021/np970382v | Vero | 2 |
| 33939429 | 10.1021/acs.jnatprod.1c00146 | RAW264.7 | 2 |
| 20476748 | 10.1021/np100013r | Candida dubliniensis | 2 |
| 23270663 | 10.1016/j.bmc.2012.11.038 | ADMET | 2 |
| 8676127 | 10.1021/np50124a001 | Sodium-dependent dopamine transporter | 1 |
| - | 10.1021/np50019a011 | KB | 1 |
| 20476748 | 10.1021/np100013r | NON-PROTEIN TARGET | 1 |
| 20476748 | 10.1021/np100013r | Kocuria rhizophila | 1 |
| 11374955 | 10.1021/np0005208 | HepG2 | 1 |
| 20476748 | 10.1021/np100013r | Staphylococcus epidermidis | 1 |
| 20476748 | 10.1021/np100013r | Escherichia coli | 1 |
| 20476748 | 10.1021/np100013r | Pseudomonas aeruginosa | 1 |
| 20476748 | 10.1021/np100013r | Candida albicans | 1 |
| 35092899 | 10.1016/j.ejmech.2022.114141 | WI-38 | 1 |
| 20476748 | 10.1021/np100013r | Nakaseomyces glabratus | 1 |
Data from ChEMBL 36 via Core Engine