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Assay Detail

CHEMBL5134516

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-OV-3
Confidence 1 — Organism
Curated By Autocuration

Target

SK-OV-3 (CHEMBL614925)
Type CELL-LINE
Organism Homo sapiens

Publication

One-pot synthesis of oxoaporphines as potent antitumor agents and investigation of their mechanisms of actions.
Liao LS, Tan LJ, Chen Y, Yang QY, Choudhary MI, Pan YM, Tang HT, Su GF, Liang H, Chen ZF.
Eur J Med Chem (2022) 231 : 114141 -114141
PubMed 35092899 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.66 5.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5205285 1 5.05
CHEMBL5180036 1 4.98
CHEMBL510090 LYSICAMINE 1 4.92
CHEMBL5189439 1 4.80
CHEMBL5170403 1 4.78
CHEMBL5189283 1 4.77
CHEMBL5188264 1 4.73
CHEMBL5194973 1 4.71
CHEMBL185 FLUOROURACIL 4.0 1 4.67
CHEMBL5191341 1 4.66
CHEMBL5202109 1 4.65
CHEMBL5181280 1 4.58
CHEMBL5200034 1 4.57
CHEMBL5186529 1 4.56
CHEMBL5178252 1 4.56
CHEMBL5207732 1 4.53
CHEMBL5180509 1 4.48
CHEMBL559502 1 4.43
CHEMBL5195089 1 4.42
CHEMBL5192797 1 4.42
CHEMBL5205405 1 -
CHEMBL5203845 1 -
CHEMBL5197018 1 -
CHEMBL5171762 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5205285 IC50 = 8900.0 nM 5.05
CHEMBL5180036 IC50 = 10400.0 nM 4.98
CHEMBL510090 LYSICAMINE IC50 = 12100.0 nM 4.92
CHEMBL5189439 IC50 = 16000.0 nM 4.80
CHEMBL5170403 IC50 = 16700.0 nM 4.78
CHEMBL5189283 IC50 = 17000.0 nM 4.77
CHEMBL5188264 IC50 = 18500.0 nM 4.73
CHEMBL5194973 IC50 = 19400.0 nM 4.71
CHEMBL185 FLUOROURACIL IC50 = 21600.0 nM 4.67
CHEMBL5191341 IC50 = 22100.0 nM 4.66
CHEMBL5202109 IC50 = 22300.0 nM 4.65
CHEMBL5181280 IC50 = 26100.0 nM 4.58
CHEMBL5200034 IC50 = 27200.0 nM 4.57
CHEMBL5186529 IC50 = 27400.0 nM 4.56
CHEMBL5178252 IC50 = 27400.0 nM 4.56
CHEMBL5207732 IC50 = 29400.0 nM 4.53
CHEMBL5180509 IC50 = 32900.0 nM 4.48
CHEMBL559502 IC50 = 37000.0 nM 4.43
CHEMBL5195089 IC50 = 38100.0 nM 4.42
CHEMBL5192797 IC50 = 38400.0 nM 4.42
CHEMBL5205405 IC50 > 40000.0 nM -
CHEMBL5203845 IC50 > 40000.0 nM -
CHEMBL5197018 IC50 > 40000.0 nM -
CHEMBL5171762 IC50 > 40000.0 nM -