Assay Detail
Functional
CHEMBL4813205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New camptothecin derivatives for generalized oncological chemotherapy: Synthesis, stereochemistry and biology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.84 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 7.55 |
| CHEMBL4848652 | — | — | 1 | 6.69 |
| CHEMBL4871226 | — | — | 1 | 6.57 |
| CHEMBL4865556 | — | — | 1 | 6.39 |
| CHEMBL4851112 | — | — | 1 | 5.93 |
| CHEMBL4846524 | — | — | 1 | 5.71 |
| CHEMBL4854308 | — | — | 1 | 5.37 |
| CHEMBL4859129 | — | — | 1 | 5.28 |
| CHEMBL4870090 | — | — | 1 | 5.18 |
| CHEMBL4867506 | — | — | 1 | 4.96 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4848652 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL4871226 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL4865556 | — | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL4851112 | — | IC50 | = | 1165.0 | nM | 5.93 |
| CHEMBL4846524 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL4854308 | — | IC50 | = | 4268.0 | nM | 5.37 |
| CHEMBL4859129 | — | IC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL4870090 | — | IC50 | = | 6536.0 | nM | 5.18 |
| CHEMBL4867506 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 26690.0 | nM | 4.57 |