Assay Detail
Functional
CHEMBL4813288
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV-1 IIIB infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect measured after 5 days by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 7.11 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4857180 | — | — | 1 | 9.00 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.52 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.52 |
| CHEMBL4870132 | — | — | 1 | 7.80 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.68 |
| CHEMBL4875791 | — | — | 1 | 7.66 |
| CHEMBL4865294 | — | — | 1 | 7.54 |
| CHEMBL4848174 | — | — | 1 | 7.46 |
| CHEMBL4855832 | — | — | 1 | 7.46 |
| CHEMBL4847581 | — | — | 1 | 7.13 |
| CHEMBL4854160 | — | — | 1 | 7.10 |
| CHEMBL4877140 | — | — | 1 | 7.01 |
| CHEMBL4852301 | — | — | 1 | 6.94 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.80 |
| CHEMBL4877110 | — | — | 1 | 6.77 |
| CHEMBL4848195 | — | — | 1 | 6.73 |
| CHEMBL4853712 | — | — | 1 | 6.42 |
| CHEMBL4858301 | — | — | 1 | 6.19 |
| CHEMBL4879260 | — | — | 1 | 6.18 |
| CHEMBL18314 | — | — | 1 | 5.28 |
| CHEMBL4861385 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4857180 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4870132 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4875791 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4865294 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4848174 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4855832 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4847581 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4854160 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4877140 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4852301 | — | EC50 | = | 114.0 | nM | 6.94 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4877110 | — | EC50 | = | 171.0 | nM | 6.77 |
| CHEMBL4848195 | — | EC50 | = | 187.0 | nM | 6.73 |
| CHEMBL4853712 | — | EC50 | = | 376.0 | nM | 6.42 |
| CHEMBL4858301 | — | EC50 | = | 643.0 | nM | 6.19 |
| CHEMBL4879260 | — | EC50 | = | 656.0 | nM | 6.18 |
| CHEMBL18314 | — | EC50 | = | 5234.0 | nM | 5.28 |
| CHEMBL4861385 | — | EC50 | = | 7048.0 | nM | 5.15 |