Assay Detail
Functional
CHEMBL4813296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 harboring RT E138K mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect incubated for 5 days by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 6.50 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4857180 | — | — | 1 | 8.22 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.15 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.72 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.46 |
| CHEMBL4875791 | — | — | 1 | 6.77 |
| CHEMBL4865294 | — | — | 1 | 6.77 |
| CHEMBL4870132 | — | — | 1 | 6.69 |
| CHEMBL4848174 | — | — | 1 | 6.62 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.59 |
| CHEMBL4855832 | — | — | 1 | 6.58 |
| CHEMBL4854160 | — | — | 1 | 6.31 |
| CHEMBL4877140 | — | — | 1 | 6.16 |
| CHEMBL4852301 | — | — | 1 | 6.12 |
| CHEMBL4847581 | — | — | 1 | 6.09 |
| CHEMBL4877110 | — | — | 1 | 6.04 |
| CHEMBL4848195 | — | — | 1 | 5.67 |
| CHEMBL4879260 | — | — | 1 | 5.26 |
| CHEMBL4853712 | — | — | 1 | 5.26 |
| CHEMBL18314 | — | — | 1 | 5.08 |
| CHEMBL4861385 | — | — | 1 | - |
| CHEMBL4858301 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4857180 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4875791 | — | EC50 | = | 171.0 | nM | 6.77 |
| CHEMBL4865294 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4870132 | — | EC50 | = | 204.0 | nM | 6.69 |
| CHEMBL4848174 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 258.0 | nM | 6.59 |
| CHEMBL4855832 | — | EC50 | = | 265.0 | nM | 6.58 |
| CHEMBL4854160 | — | EC50 | = | 493.0 | nM | 6.31 |
| CHEMBL4877140 | — | EC50 | = | 685.0 | nM | 6.16 |
| CHEMBL4852301 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4847581 | — | EC50 | = | 805.0 | nM | 6.09 |
| CHEMBL4877110 | — | EC50 | = | 918.0 | nM | 6.04 |
| CHEMBL4848195 | — | EC50 | = | 2149.0 | nM | 5.67 |
| CHEMBL4879260 | — | EC50 | = | 5465.0 | nM | 5.26 |
| CHEMBL4853712 | — | EC50 | = | 5456.0 | nM | 5.26 |
| CHEMBL18314 | — | EC50 | = | 8266.0 | nM | 5.08 |
| CHEMBL4861385 | — | EC50 | > | 201162.0 | nM | - |
| CHEMBL4858301 | — | EC50 | > | 56735.0 | nM | - |