Assay Detail
Binding
CHEMBL4813795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human CA7 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.85 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 9.05 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.60 |
| CHEMBL4632436 | — | — | 1 | 8.54 |
| CHEMBL4876892 | — | — | 1 | 8.37 |
| CHEMBL4873540 | — | — | 1 | 8.15 |
| CHEMBL4875463 | — | — | 1 | 8.14 |
| CHEMBL4852567 | — | — | 1 | 8.12 |
| CHEMBL4863183 | — | — | 1 | 8.08 |
| CHEMBL4876588 | — | — | 1 | 8.03 |
| CHEMBL4856098 | — | — | 1 | 7.81 |
| CHEMBL4864679 | — | — | 1 | 7.67 |
| CHEMBL4862904 | — | — | 1 | 7.25 |
| CHEMBL4869644 | — | — | 1 | 7.24 |
| CHEMBL4878898 | — | — | 1 | 7.17 |
| CHEMBL4643115 | — | — | 1 | 7.15 |
| CHEMBL4869570 | — | — | 1 | 7.08 |
| CHEMBL4855985 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220492 | TOPIRAMATE | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL4632436 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL4876892 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL4873540 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL4875463 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL4852567 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL4863183 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL4876588 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL4856098 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL4864679 | — | Ki | = | 21.5 | nM | 7.67 |
| CHEMBL4862904 | — | Ki | = | 56.4 | nM | 7.25 |
| CHEMBL4869644 | — | Ki | = | 57.9 | nM | 7.24 |
| CHEMBL4878898 | — | Ki | = | 68.3 | nM | 7.17 |
| CHEMBL4643115 | — | Ki | = | 70.7 | nM | 7.15 |
| CHEMBL4869570 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL4855985 | — | Ki | = | 82.5 | nM | 7.08 |