Assay Detail
Binding
CHEMBL4814103
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Binding affinity to hairpin DNA Hoxa9-binding site 5'-biotin-CCATGATTTACCTCTGTAAATCATGG (unknown origin) by surface plasmon resonance
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 8.30 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1232046 | — | — | 1 | 8.34 |
| CHEMBL1234147 | — | — | 1 | 8.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1232046 | — | Kd | = | 4.6 | nM | 8.34 |
| CHEMBL1234147 | — | Kd | = | 5.5 | nM | 8.26 |