Assay Detail
Binding
CHEMBL4814514
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Inhibition of Salmonella typhimurium LsrK expressed in Escherichia coli MET1158 in presence of DPD by kinase-glo max luminescent assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tackling Antimicrobial Resistance with Small Molecules Targeting LsrK: Challenges and Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.53 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4873605 | — | — | 1 | 4.92 |
| CHEMBL4854381 | — | — | 1 | 4.82 |
| CHEMBL3898662 | — | — | 1 | 4.75 |
| CHEMBL4855369 | — | — | 1 | 4.75 |
| CHEMBL4872256 | — | — | 1 | 4.54 |
| CHEMBL3961002 | — | — | 1 | 4.52 |
| CHEMBL522174 | — | — | 1 | 4.17 |
| CHEMBL121626 | TOLFENAMIC ACID | 2.0 | 1 | 4.16 |
| CHEMBL4877532 | — | — | 1 | 4.11 |
| CHEMBL1230640 | — | — | 1 | - |
| CHEMBL509 | MECLOFENAMIC ACID | 4.0 | 1 | - |
| CHEMBL4878358 | — | — | 1 | - |
| CHEMBL22815 | — | — | 1 | - |
| CHEMBL2043303 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4873605 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4854381 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3898662 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4855369 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4872256 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3961002 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL522174 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL121626 | TOLFENAMIC ACID | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL4877532 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL1230640 | — | IC50 | = | 292000.0 | nM | - |
| CHEMBL509 | MECLOFENAMIC ACID | IC50 | = | 178000.0 | nM | - |
| CHEMBL4878358 | — | IC50 | = | 147000.0 | nM | - |
| CHEMBL22815 | — | IC50 | = | 119000.0 | nM | - |
| CHEMBL2043303 | — | IC50 | = | 141000.0 | nM | - |