Assay Detail
Functional
CHEMBL4814518
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Inhibition of GST-tagged recombinant RANKL/M-CSF-induced osteoclastogenesis in C57BL/6 mouse bone marrow derived macrophages assessed as TRAcP enzymatic activity incubated for 5 days with subsequent replenishment of media for 2 days and measured by leucocyte acid phosphatase staining method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BMDM |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Deep learning enables discovery of highly potent anti-osteoporosis natural products.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.44 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4861437 | — | — | 1 | 7.50 |
| CHEMBL4848923 | — | — | 1 | 7.17 |
| CHEMBL186141 | ANDROGRAPHOLIDE | 3.0 | 1 | 6.26 |
| CHEMBL4852218 | — | — | 1 | 5.76 |
| CHEMBL278779 | KOKUSAGININE | — | 1 | 5.50 |
| CHEMBL4850577 | — | — | 1 | - |
| CHEMBL4869645 | — | — | 1 | - |
| CHEMBL503675 | MACULINE | — | 1 | - |
| CHEMBL519894 | — | — | 1 | - |
| CHEMBL317469 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4861437 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4848923 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL186141 | ANDROGRAPHOLIDE | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4852218 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL278779 | KOKUSAGININE | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL4850577 | — | IC50 | - | — | - | |
| CHEMBL4869645 | — | IC50 | - | — | - | |
| CHEMBL503675 | MACULINE | IC50 | - | — | - | |
| CHEMBL519894 | — | IC50 | - | — | - | |
| CHEMBL317469 | — | IC50 | - | — | - |