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Assay Detail

CHEMBL4814673

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of porcine pancreatic alpha-amylase using 1% starch as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by absorbance method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Pancreatic alpha-amylase (CHEMBL5730)
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective.
Patel OPS, Jesumoroti OJ, Legoabe LJ, Beteck RM.
Eur J Med Chem (2021) 210 : 112994 -112994
PubMed 33234343 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.99 6.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4861741 1 6.42
CHEMBL4864128 1 5.78
CHEMBL404271 ACARBOSE 4.0 1 5.78
CHEMBL188521 1 -
CHEMBL4854163 1 -
CHEMBL4851123 1 -
CHEMBL4846195 1 -
CHEMBL4865236 1 -
CHEMBL4866987 1 -
CHEMBL4875625 1 -
CHEMBL4868815 1 -
CHEMBL4860734 1 -
CHEMBL4869717 1 -
CHEMBL4876409 1 -
CHEMBL4876278 1 -
CHEMBL4859800 1 -
CHEMBL4859605 1 -
CHEMBL4867711 1 -
CHEMBL4866166 1 -
CHEMBL4866437 1 -
CHEMBL4871075 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4861741 IC50 = 380.0 nM 6.42
CHEMBL4864128 IC50 = 1660.0 nM 5.78
CHEMBL404271 ACARBOSE IC50 = 1660.0 nM 5.78
CHEMBL188521 IC50 < 2980.0 nM -
CHEMBL4854163 IC50 < 2980.0 nM -
CHEMBL4851123 IC50 < 2980.0 nM -
CHEMBL4846195 IC50 < 2980.0 nM -
CHEMBL4865236 IC50 < 2980.0 nM -
CHEMBL4866987 IC50 < 2980.0 nM -
CHEMBL4875625 IC50 < 2980.0 nM -
CHEMBL4868815 IC50 < 2980.0 nM -
CHEMBL4860734 IC50 < 2980.0 nM -
CHEMBL4869717 IC50 < 2980.0 nM -
CHEMBL4876409 IC50 < 2980.0 nM -
CHEMBL4876278 IC50 < 2980.0 nM -
CHEMBL4859800 IC50 < 2980.0 nM -
CHEMBL4859605 IC50 < 2980.0 nM -
CHEMBL4867711 IC50 < 2980.0 nM -
CHEMBL4866166 IC50 < 2980.0 nM -
CHEMBL4866437 IC50 < 2980.0 nM -
CHEMBL4871075 IC50 < 2980.0 nM -