Assay Detail
Binding
CHEMBL4814911
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant His-tagged human FLT3 (564 to 958 residues) expressed in baculovirus expression system using tyr 02 as substrate incubated for 1 hr by Z'-LYTE assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.10 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293776 | HISPIDULIN | — | 1 | 6.36 |
| CHEMBL376644 | SALVIGENIN | — | 1 | 6.26 |
| CHEMBL78010 | PECTOLINARIGENIN | — | 1 | 6.19 |
| CHEMBL243664 | ACACETIN | — | 1 | 6.06 |
| CHEMBL487402 | EUPATORIN | — | 1 | 5.96 |
| CHEMBL210635 | GENKWANIN | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293776 | HISPIDULIN | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL376644 | SALVIGENIN | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL78010 | PECTOLINARIGENIN | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL243664 | ACACETIN | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL487402 | EUPATORIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL210635 | GENKWANIN | IC50 | = | 1700.0 | nM | 5.77 |