Compound Detail
CHEMBL376644
SALVIGENIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL376644 |
| Name | SALVIGENIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QCDYOIZVELGOLZ-UHFFFAOYSA-N |
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
18
Publications
0
Known Names
Molecular Properties
328.3
MW (Da)
3.19
ALogP
6
HBA
1
HBD
78.1
PSA (Ų)
0.79
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 6.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 6.54 | 6.3467 | 290.0 | 3 |
| MOLM-13 CHEMBL3706572 | IC50 | 5.58 | 5.58 | 2600.0 | 1 |
| MV4-11 CHEMBL613835 | IC50 | 5.58 | 5.58 | 2600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 290.0 | nM | 6.54 | Inhibition of recombinant His-tagged human FLT3 D835Y mutant (564 to 958 residue... | 33393294 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 550.0 | nM | 6.26 | Inhibition of recombinant His-tagged human FLT3 (564 to 958 residues) expressed ... | 33393294 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 580.0 | nM | 6.24 | Inhibition of recombinant N-terminal GST/His6-tagged human FLT3 ITD mutant (571 ... | 33393294 |
| MOLM-13 | IC50 | = | 2600.0 | nM | 5.58 | Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability... | 33393294 |
| MV4-11 | IC50 | = | 2600.0 | nM | 5.58 | Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability ... | 33393294 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33393294 | 10.1021/acs.jnatprod.0c00589 | MV4-11 | 18 |
| 33393294 | 10.1021/acs.jnatprod.0c00589 | MOLM-13 | 18 |
| 26523667 | 10.1016/j.ejmech.2015.10.039 | No relevant target | 5 |
| 33393294 | 10.1021/acs.jnatprod.0c00589 | Receptor-type tyrosine-protein kinase FLT3 | 4 |
| 26523667 | 10.1016/j.ejmech.2015.10.039 | Plasma | 4 |
| 26035635 | 10.1021/acs.jnatprod.5b00218 | Delta-type opioid receptor | 3 |
| 26523667 | 10.1016/j.ejmech.2015.10.039 | NON-PROTEIN TARGET | 2 |
| 26035635 | 10.1021/acs.jnatprod.5b00218 | Cannabinoid receptor 1 | 1 |
| 37625387 | 10.1021/acs.jnatprod.3c00099 | Xanthine dehydrogenase/oxidase | 1 |
| 26035635 | 10.1021/acs.jnatprod.5b00218 | Kappa-type opioid receptor | 1 |
| 17279798 | 10.1021/np060534z | MCF7 | 1 |
| 26035635 | 10.1021/acs.jnatprod.5b00218 | Cannabinoid receptor 2 | 1 |
| 24476568 | 10.1021/np400778m | Nuclear factor erythroid 2-related factor 2 | 1 |
| 17279798 | 10.1021/np060534z | HUVEC | 1 |
| 17279798 | 10.1021/np060534z | TERT-RPE1 | 1 |
| 17279798 | 10.1021/np060534z | LNCaP | 1 |
| 17279798 | 10.1021/np060534z | Col2 | 1 |
| 17279798 | 10.1021/np060534z | Lu1 | 1 |
Data from ChEMBL 36 via Core Engine