Assay Detail
Functional
CHEMBL4814916
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.26 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376644 | SALVIGENIN | — | 1 | 5.58 |
| CHEMBL243664 | ACACETIN | — | 1 | 5.17 |
| CHEMBL293776 | HISPIDULIN | — | 1 | 5.17 |
| CHEMBL78010 | PECTOLINARIGENIN | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376644 | SALVIGENIN | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL243664 | ACACETIN | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL293776 | HISPIDULIN | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL78010 | PECTOLINARIGENIN | IC50 | = | 7900.0 | nM | 5.10 |