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Assay Detail

CHEMBL4815375

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Immunosuppressive activity in BALB/c mouse splenocytes assessed as inhibition of concanavalin A-stimulated T-cell proliferation incubated for 48 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type Splenocyte
Confidence 1 — Organism
Curated By Autocuration

Target

Splenocyte (CHEMBL612422)
Type CELL-LINE
Organism Mus musculus

Publication

Hypothemycin-Type Resorcylic Acid Lactones with Immunosuppressive Activities from a <i>Podospora</i> sp.
Gao Y, Duan FF, Liu L, Peng XG, Meng XG, Ruan HL.
J Nat Prod (2021) 84 : 483 -494
PubMed 33544615 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.02 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL160 CYCLOSPORINE 4.0 1 6.52
CHEMBL1801950 1 5.22
CHEMBL1801951 1 5.13
CHEMBL3629247 1 5.09
CHEMBL4869449 1 4.97
CHEMBL4869254 1 4.94
CHEMBL4860053 1 4.82
CHEMBL1173442 AIGIALOMYCIN D 1 4.79
CHEMBL4856742 1 4.78
CHEMBL4856444 1 4.73
CHEMBL4852021 1 4.62
CHEMBL4852918 1 4.60
CHEMBL4846115 1 -
CHEMBL1456 MYCOPHENOLATE MOFETIL 4.0 1 -
CHEMBL4862254 1 -
CHEMBL4848684 1 -
CHEMBL4859918 1 -
CHEMBL4858781 1 -
CHEMBL4872581 1 -
CHEMBL4849751 1 -
CHEMBL4876850 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL160 CYCLOSPORINE IC50 = 300.0 nM 6.52
CHEMBL1801950 IC50 = 6000.0 nM 5.22
CHEMBL1801951 IC50 = 7400.0 nM 5.13
CHEMBL3629247 IC50 = 8100.0 nM 5.09
CHEMBL4869449 IC50 = 10600.0 nM 4.97
CHEMBL4869254 IC50 = 11400.0 nM 4.94
CHEMBL4860053 IC50 = 15200.0 nM 4.82
CHEMBL1173442 AIGIALOMYCIN D IC50 = 16300.0 nM 4.79
CHEMBL4856742 IC50 = 16500.0 nM 4.78
CHEMBL4856444 IC50 = 18800.0 nM 4.73
CHEMBL4852021 IC50 = 24100.0 nM 4.62
CHEMBL4852918 IC50 = 25100.0 nM 4.60
CHEMBL4846115 IC50 > 50000.0 nM -
CHEMBL1456 MYCOPHENOLATE MOFETIL IC50 - -
CHEMBL4862254 IC50 > 50000.0 nM -
CHEMBL4848684 IC50 > 50000.0 nM -
CHEMBL4859918 IC50 > 50000.0 nM -
CHEMBL4858781 IC50 > 50000.0 nM -
CHEMBL4872581 IC50 > 50000.0 nM -
CHEMBL4849751 IC50 > 50000.0 nM -
CHEMBL4876850 IC50 > 50000.0 nM -