Assay Detail

CHEMBL4815969

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Functional

Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 incubated for 48 hrs by resazurin dye based fluorescence assay

ChEMBL ↗

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Target

Trypanosoma brucei rhodesiense (CHEMBL612348) ↗

Open DB target context

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Trypanosoma brucei rhodesiense (CHEMBL612348) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Trypanosoma brucei rhodesiense

CHEMBL612348

Anchored from Assay target.

Protein identity Trypanosoma brucei rhodesiense

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Trypanosoma brucei rhodesiense
Confidence	1 — Organism
Curated By	Autocuration

Target

Trypanosoma brucei rhodesiense (CHEMBL612348) ↗

Type	ORGANISM
Organism	Trypanosoma brucei rhodesiense

Publication

Synthesis and evaluation of 3'-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents.

Bouton J, Furquim d'Almeida A, Maes L, Caljon G, Van Calenbergh S, Hulpia F.
Eur J Med Chem (2021) 216 : 113290 -113290
PubMed 33667845 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	8.36	9.28

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2023963	—	—	1	9.28
CHEMBL267099	TUBERCIDIN	—	1	7.44

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2023963	—	EC50	=	0.52	nM	9.28
CHEMBL267099	TUBERCIDIN	EC50	=	36.0	nM	7.44