Assay Detail
Functional
CHEMBL4815970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense assessed as parasite growth inhibition
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and evaluation of 3'-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 40 | 6.22 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859430 | — | — | 1 | 8.31 |
| CHEMBL4854963 | — | — | 1 | 8.20 |
| CHEMBL4849239 | — | — | 1 | 8.11 |
| CHEMBL72928 | — | — | 1 | 7.77 |
| CHEMBL4871173 | — | — | 1 | 7.70 |
| CHEMBL4856247 | — | — | 1 | 7.55 |
| CHEMBL4852417 | — | — | 1 | 7.51 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 7.40 |
| CHEMBL4862263 | — | — | 1 | 6.92 |
| CHEMBL4870078 | — | — | 1 | 6.80 |
| CHEMBL4853463 | — | — | 1 | 6.68 |
| CHEMBL4854535 | — | — | 1 | 6.47 |
| CHEMBL4857373 | — | — | 1 | 6.42 |
| CHEMBL4879131 | — | — | 1 | 5.84 |
| CHEMBL4846004 | — | — | 1 | 5.83 |
| CHEMBL4858295 | — | — | 1 | 5.81 |
| CHEMBL4849363 | — | — | 1 | 5.80 |
| CHEMBL4878243 | — | — | 1 | 5.76 |
| CHEMBL4860880 | — | — | 1 | 5.69 |
| CHEMBL4861248 | — | — | 1 | 5.64 |
| CHEMBL4873064 | — | — | 1 | 5.44 |
| CHEMBL4855327 | — | — | 1 | 5.29 |
| CHEMBL4849638 | — | — | 1 | 4.85 |
| CHEMBL4856223 | — | — | 1 | 4.67 |
| CHEMBL4867618 | — | — | 1 | 4.59 |
| CHEMBL4866903 | — | — | 1 | 4.49 |
| CHEMBL4863184 | — | — | 1 | 4.45 |
| CHEMBL4853123 | — | — | 1 | 4.29 |
| CHEMBL4878319 | — | — | 1 | - |
| CHEMBL4874598 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859430 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4854963 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4849239 | — | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL72928 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4871173 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4856247 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4852417 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL265502 | SURAMIN | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4862263 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4870078 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4853463 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4854535 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4857373 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4879131 | — | EC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL4846004 | — | EC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL4858295 | — | EC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4849363 | — | EC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL4878243 | — | EC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL4860880 | — | EC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL4861248 | — | EC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL4873064 | — | EC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL4855327 | — | EC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL4849638 | — | EC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4856223 | — | EC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL4867618 | — | EC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL4866903 | — | EC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL4863184 | — | EC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL4853123 | — | EC50 | = | 51600.0 | nM | 4.29 |
| CHEMBL4869277 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4853520 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4872128 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4871274 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL420751 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4865014 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4868788 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4871965 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4867811 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4852610 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4874598 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4878319 | — | EC50 | > | 64000.0 | nM | - |