Assay Detail
Functional
CHEMBL4816050
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Antiproliferative activity against human BT-474 cells overexpressing HER2 assessed as cell growth inhibition incubated for 72 hrs by cell titer glo assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A grafted peptidomimetic for EGFR heterodimerization inhibition: Implications in NSCLC models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.72 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4861037 | — | — | 1 | 6.71 |
| CHEMBL4849365 | — | — | 1 | 6.55 |
| CHEMBL4873736 | — | — | 1 | 5.53 |
| CHEMBL4847480 | — | — | 1 | 5.44 |
| CHEMBL4876757 | — | — | 1 | 5.38 |
| CHEMBL4878771 | — | — | 1 | 5.28 |
| CHEMBL4874525 | — | — | 1 | 5.14 |
| CHEMBL3218540 | — | — | 1 | - |
| CHEMBL4872992 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4861037 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL4849365 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4873736 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL4847480 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL4876757 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL4878771 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL4874525 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL3218540 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4872992 | — | IC50 | - | — | - |