Assay Detail
Functional
CHEMBL4816798
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 infected in human CEM-SS cells assessed as reduction in viral multiplication by measuring decrease in reverse transcriptase activity incubated for 5 days
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
An original pronucleotide strategy for the simultaneous delivery of two bioactive drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.42 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4856158 | — | — | 1 | 9.22 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.62 |
| CHEMBL4853086 | — | — | 1 | 7.40 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 7.17 |
| CHEMBL23094 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4856158 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4853086 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL853 | ZALCITABINE | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL23094 | — | EC50 | = | 2000.0 | nM | 5.70 |