Assay Detail
Functional
CHEMBL4816807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 infected in human MT4 cells assessed as reduction in virus-indued cytopathogenicity incubated for 5 days by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
An original pronucleotide strategy for the simultaneous delivery of two bioactive drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.56 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4856158 | — | — | 1 | 8.19 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.77 |
| CHEMBL4853086 | — | — | 1 | 6.10 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 5.70 |
| CHEMBL23094 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4856158 | — | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4853086 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL853 | ZALCITABINE | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL23094 | — | EC50 | = | 9000.0 | nM | 5.05 |