Assay Detail
Functional
CHEMBL4817100
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Antiproliferative activity against human BRCA-2 deficient HCT-116 cells assessed as reduction in cell growth incubated for 7 days by cell titer-glo assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel and potent PARP/PI3K dual inhibitors for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.89 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4865059 | — | — | 1 | 6.55 |
| CHEMBL4858564 | — | — | 1 | 6.51 |
| CHEMBL4861171 | — | — | 1 | 6.16 |
| CHEMBL4875356 | — | — | 1 | 6.16 |
| CHEMBL4856241 | — | — | 1 | 6.05 |
| CHEMBL1922094 | APITOLISIB | 2.0 | 1 | 5.96 |
| CHEMBL4859625 | — | — | 1 | 5.63 |
| CHEMBL4868711 | — | — | 1 | 5.40 |
| CHEMBL4874038 | — | — | 1 | 5.29 |
| CHEMBL4853655 | — | — | 1 | 5.23 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4865059 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4858564 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4861171 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4875356 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4856241 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL1922094 | APITOLISIB | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4859625 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL4868711 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL4874038 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL4853655 | — | IC50 | = | 5840.0 | nM | 5.23 |
| CHEMBL521686 | OLAPARIB | IC50 | > | 10000.0 | nM | - |