Assay Detail
Binding
CHEMBL4817811
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Inhibition of DNA topoisomerase 1 (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation, and correlation of cytotoxicity versus redox potential of 1,4-naphthoquinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.43 | 5.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43612 | JUGLONE | — | 1 | 5.08 |
| CHEMBL1989223 | — | — | 1 | 4.32 |
| CHEMBL4849493 | — | — | 1 | 4.27 |
| CHEMBL4875317 | — | — | 1 | 4.04 |
| CHEMBL4868524 | — | — | 1 | - |
| CHEMBL4874528 | — | — | 1 | - |
| CHEMBL4853584 | — | — | 1 | - |
| CHEMBL4855264 | — | — | 1 | - |
| CHEMBL4860854 | — | — | 1 | - |
| CHEMBL4858591 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43612 | JUGLONE | IC50 | = | 8260.0 | nM | 5.08 |
| CHEMBL1989223 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL4849493 | — | IC50 | = | 53660.0 | nM | 4.27 |
| CHEMBL4875317 | — | IC50 | = | 90560.0 | nM | 4.04 |
| CHEMBL4868524 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4874528 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4853584 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4855264 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4860854 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4858591 | — | IC50 | > | 100000.0 | nM | - |