Assay Detail
Functional
CHEMBL4819405
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Antiproliferative activity against human K562/A02 cells by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562/A02 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010-2020).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.34 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4845962 | — | — | 1 | 7.00 |
| CHEMBL4852246 | — | — | 1 | 7.00 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.70 |
| CHEMBL4850811 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4845962 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4852246 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4850811 | — | IC50 | = | 2230.0 | nM | 5.65 |