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Assay Detail

CHEMBL4819552

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha release measured after 24 hrs by ELISA
ChEMBL ↗
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type RAW264.7
Confidence 1 — Organism
Curated By Autocuration

Target

RAW264.7 (CHEMBL612557) ↗
Type CELL-LINE
Organism Mus musculus

Publication

Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.
Zhang R, Li H, Zhang X, Li J, Su H, Lu Q, Dong G, Dou H, Fan C, Gu Z, Mu Q, Tang W, Xu Y, Liu H.
Eur J Med Chem (2021) 211 : 113004 -113004
PubMed 33218684 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 52 4.63 4.86

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4876481 — — 1 4.86
CHEMBL4848137 — — 1 4.84
CHEMBL4863785 — — 1 4.83
CHEMBL4857463 — — 1 4.54
CHEMBL4875765 — — 1 4.46
CHEMBL4877238 — — 1 4.43
CHEMBL4867813 — — 1 4.43
CHEMBL4864276 — — 1 -
CHEMBL4871062 — — 1 -
CHEMBL4860020 — — 1 -
CHEMBL4851187 — — 1 -
CHEMBL4855051 — — 1 -
CHEMBL4849482 — — 1 -
CHEMBL4868218 — — 1 -
CHEMBL4875449 — — 1 -
CHEMBL4847332 — — 1 -
CHEMBL4846129 — — 1 -
CHEMBL4874067 — — 1 -
CHEMBL4863942 — — 1 -
CHEMBL4853858 — — 1 -
CHEMBL4868870 — — 1 -
CHEMBL4862306 — — 1 -
CHEMBL4871685 — — 1 -
CHEMBL4876519 — — 1 -
CHEMBL4875548 — — 1 -
CHEMBL4864866 — — 1 -
CHEMBL4865887 — — 1 -
CHEMBL4855517 — — 1 -
CHEMBL4873094 — — 1 -
CHEMBL4846300 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4876481 — IC50 = 13800.0 nM 4.86
CHEMBL4848137 — IC50 = 14500.0 nM 4.84
CHEMBL4863785 — IC50 = 14800.0 nM 4.83
CHEMBL4857463 — IC50 = 29200.0 nM 4.54
CHEMBL4875765 — IC50 = 34900.0 nM 4.46
CHEMBL4877238 — IC50 = 36700.0 nM 4.43
CHEMBL4867813 — IC50 = 37500.0 nM 4.43
CHEMBL4874635 — IC50 > 50000.0 nM -
CHEMBL4871062 — IC50 > 50000.0 nM -
CHEMBL4851163 — IC50 > 50000.0 nM -
CHEMBL4872850 — IC50 > 50000.0 nM -
CHEMBL4856152 — IC50 > 50000.0 nM -
CHEMBL4875582 — IC50 > 50000.0 nM -
CHEMBL4849551 — IC50 > 50000.0 nM -
CHEMBL4859189 — IC50 > 50000.0 nM -
CHEMBL4859738 — IC50 > 50000.0 nM -
CHEMBL4859761 — IC50 > 50000.0 nM -
CHEMBL4848321 — IC50 > 50000.0 nM -
CHEMBL4874498 — IC50 > 50000.0 nM -
CHEMBL4466435 — IC50 > 50000.0 nM -
CHEMBL4864960 — IC50 > 50000.0 nM -
CHEMBL4853453 — IC50 > 50000.0 nM -
CHEMBL4868930 — IC50 > 50000.0 nM -
CHEMBL4867142 — IC50 > 50000.0 nM -
CHEMBL4862887 — IC50 > 50000.0 nM -
CHEMBL4865688 — IC50 > 50000.0 nM -
CHEMBL4859162 — IC50 > 50000.0 nM -
CHEMBL4866565 — IC50 > 50000.0 nM -
CHEMBL4853858 — IC50 > 50000.0 nM -
CHEMBL4846300 — IC50 - — -
CHEMBL4873094 — IC50 > 50000.0 nM -
CHEMBL4855517 — IC50 > 50000.0 nM -
CHEMBL4865887 — IC50 > 50000.0 nM -
CHEMBL4864866 — IC50 > 50000.0 nM -
CHEMBL4875548 — IC50 > 50000.0 nM -
CHEMBL4876519 — IC50 > 50000.0 nM -
CHEMBL4871685 — IC50 > 50000.0 nM -
CHEMBL4862306 — IC50 > 50000.0 nM -
CHEMBL4868870 — IC50 - — -
CHEMBL4874067 — IC50 > 50000.0 nM -
CHEMBL4863942 — IC50 > 50000.0 nM -
CHEMBL4864276 — IC50 > 50000.0 nM -
CHEMBL4860020 — IC50 > 50000.0 nM -
CHEMBL4851187 — IC50 - — -
CHEMBL4855051 — IC50 - — -
CHEMBL4849482 — IC50 - — -
CHEMBL4868218 — IC50 - — -
CHEMBL4875449 — IC50 - — -
CHEMBL4847332 — IC50 - — -
CHEMBL4846129 — IC50 > 50000.0 nM -