Assay Detail
Binding
CHEMBL4819612
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST-tagged human recombinant EGFR L861Q mutant (668 to 1210 residues) expressed in baculovirus expression system by Z'-LYTE kinase assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual nicotinamide phosphoribosyltransferase and epidermal growth factor receptor inhibitors for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.27 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4851176 | — | — | 1 | 9.59 |
| CHEMBL4860398 | — | — | 1 | 9.44 |
| CHEMBL4873506 | — | — | 1 | 9.42 |
| CHEMBL4852664 | — | — | 1 | 9.34 |
| CHEMBL4859375 | — | — | 1 | 9.31 |
| CHEMBL4868614 | — | — | 1 | 9.26 |
| CHEMBL1229592 | — | — | 1 | 8.54 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4851176 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL4860398 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL4873506 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL4852664 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL4859375 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL4868614 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL1229592 | — | IC50 | = | 2.86 | nM | 8.54 |
| CHEMBL566757 | DAPORINAD | IC50 | - | — | - |