Assay Detail
Functional
CHEMBL4819614
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Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth after 72 hrs by CCK8 assay
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dual nicotinamide phosphoribosyltransferase and epidermal growth factor receptor inhibitors for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| GI50 | 6 | - | - |
| IC50 | 1 | 8.10 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4873506 | — | — | 1 | 8.10 |
| CHEMBL4860398 | — | — | 1 | - |
| CHEMBL4851176 | — | — | 1 | - |
| CHEMBL4852664 | — | — | 1 | - |
| CHEMBL4868614 | — | — | 1 | - |
| CHEMBL4859375 | — | — | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4873506 | — | IC50 | = | 8.02 | nM | 8.10 |
| CHEMBL4860398 | — | GI50 | = | 1.87 | nM | - |
| CHEMBL4851176 | — | GI50 | = | 1.64 | nM | - |
| CHEMBL4852664 | — | GI50 | = | 62.9 | nM | - |
| CHEMBL4868614 | — | GI50 | = | 1.81 | nM | - |
| CHEMBL4859375 | — | GI50 | = | 9.94 | nM | - |
| CHEMBL428647 | PACLITAXEL | GI50 | = | 7.41 | nM | - |