Assay Detail
Functional
CHEMBL4819638
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Antibacterial activity against Mycobacterium tuberculosis H37Ra ATCC2517 assessed as inhibition of bacterial growth measured after 17 hrs by resazurin based flourimetric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.07 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64 | ISONIAZID | 4.0 | 1 | 7.00 |
| CHEMBL32 | MOXIFLOXACIN | 4.0 | 1 | 6.60 |
| CHEMBL4869028 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64 | ISONIAZID | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL32 | MOXIFLOXACIN | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4869028 | — | IC50 | = | 24700.0 | nM | 4.61 |