Assay Detail
Binding
CHEMBL4819975
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Inhibition of human BTK using poly (Glu,Tyr) as substrate in presence of ATP and Ci(gamma33-P) ATP measured by microplate reader assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,4,6-Trisubstituted imidazo[4,5-c]pyridines as inhibitors of Bruton's tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.90 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3647964 | — | — | 1 | 7.72 |
| CHEMBL4858294 | — | — | 1 | 7.60 |
| CHEMBL4865664 | — | — | 1 | 7.57 |
| CHEMBL4875035 | — | — | 1 | 7.46 |
| CHEMBL4852342 | — | — | 1 | 7.39 |
| CHEMBL4873565 | — | — | 1 | 7.10 |
| CHEMBL4867619 | — | — | 1 | 6.81 |
| CHEMBL4852053 | — | — | 1 | 6.78 |
| CHEMBL4879055 | — | — | 1 | 6.58 |
| CHEMBL4855825 | — | — | 1 | 6.28 |
| CHEMBL4859682 | — | — | 1 | 6.26 |
| CHEMBL4868893 | — | — | 1 | 6.15 |
| CHEMBL4869977 | — | — | 1 | 6.03 |
| CHEMBL4854403 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3647964 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4858294 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4865664 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4875035 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4852342 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4873565 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4867619 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL4852053 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL4879055 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL4855825 | — | IC50 | = | 527.0 | nM | 6.28 |
| CHEMBL4859682 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL4868893 | — | IC50 | = | 709.0 | nM | 6.15 |
| CHEMBL4869977 | — | IC50 | = | 932.0 | nM | 6.03 |
| CHEMBL4854403 | — | IC50 | > | 10000.0 | nM | - |