Assay Detail
Binding
CHEMBL4821054
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Binding affinity to 5-HT1A receptor (unknown origin)
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.43 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2387229 | — | — | 1 | 8.48 |
| CHEMBL4861643 | — | — | 1 | 8.36 |
| CHEMBL4867978 | — | — | 1 | 8.25 |
| CHEMBL3883955 | — | — | 1 | 8.23 |
| CHEMBL4861311 | — | — | 1 | 8.13 |
| CHEMBL4289498 | — | — | 1 | 8.07 |
| CHEMBL4861193 | — | — | 1 | 8.02 |
| CHEMBL4865907 | — | — | 1 | 7.92 |
| CHEMBL4846866 | — | — | 1 | 7.91 |
| CHEMBL4857918 | — | — | 1 | 7.79 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 7.70 |
| CHEMBL4870307 | — | — | 1 | 7.17 |
| CHEMBL4877940 | — | — | 1 | 7.11 |
| CHEMBL4879054 | — | — | 1 | 7.10 |
| CHEMBL4852663 | — | — | 1 | 7.09 |
| CHEMBL4870716 | — | — | 1 | 7.07 |
| CHEMBL4865735 | — | — | 1 | 7.05 |
| CHEMBL4857350 | — | — | 1 | 7.05 |
| CHEMBL4876719 | — | — | 1 | 7.04 |
| CHEMBL4859348 | — | — | 1 | 7.04 |
| CHEMBL4878271 | — | — | 1 | 7.04 |
| CHEMBL4856753 | — | — | 1 | 7.02 |
| CHEMBL4877973 | — | — | 1 | 7.00 |
| CHEMBL4860828 | — | — | 1 | 7.00 |
| CHEMBL4853342 | — | — | 1 | 6.98 |
| CHEMBL4873319 | — | — | 1 | 6.95 |
| CHEMBL4863980 | — | — | 1 | 6.82 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2387229 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL4861643 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL4867978 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL3883955 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL4861311 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL4289498 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL4861193 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL4865907 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL4846866 | — | Ki | = | 12.4 | nM | 7.91 |
| CHEMBL4857918 | — | Ki | = | 16.4 | nM | 7.79 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 19.8 | nM | 7.70 |
| CHEMBL4870307 | — | Ki | = | 67.7 | nM | 7.17 |
| CHEMBL4877940 | — | Ki | = | 77.9 | nM | 7.11 |
| CHEMBL4879054 | — | Ki | = | 79.2 | nM | 7.10 |
| CHEMBL4852663 | — | Ki | = | 81.6 | nM | 7.09 |
| CHEMBL4870716 | — | Ki | = | 85.5 | nM | 7.07 |
| CHEMBL4865735 | — | Ki | = | 89.7 | nM | 7.05 |
| CHEMBL4857350 | — | Ki | = | 89.3 | nM | 7.05 |
| CHEMBL4876719 | — | Ki | = | 92.1 | nM | 7.04 |
| CHEMBL4859348 | — | Ki | = | 90.6 | nM | 7.04 |
| CHEMBL4878271 | — | Ki | = | 92.2 | nM | 7.04 |
| CHEMBL4856753 | — | Ki | = | 95.4 | nM | 7.02 |
| CHEMBL4877973 | — | Ki | = | 100.2 | nM | 7.00 |
| CHEMBL4860828 | — | Ki | = | 100.1 | nM | 7.00 |
| CHEMBL4853342 | — | Ki | = | 105.2 | nM | 6.98 |
| CHEMBL4873319 | — | Ki | = | 112.1 | nM | 6.95 |
| CHEMBL4863980 | — | Ki | = | 152.2 | nM | 6.82 |
| CHEMBL85 | RISPERIDONE | Ki | = | 182.0 | nM | 6.74 |