Assay Detail
Binding
CHEMBL4821060
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Binding affinity to histamine H3 receptor (unknown origin)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.96 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4865907 | — | — | 1 | 8.09 |
| CHEMBL4846866 | — | — | 1 | 8.04 |
| CHEMBL4861193 | — | — | 1 | 7.92 |
| CHEMBL4861311 | — | — | 1 | 7.87 |
| CHEMBL4867978 | — | — | 1 | 7.85 |
| CHEMBL4861643 | — | — | 1 | 7.80 |
| CHEMBL4852663 | — | — | 1 | 7.03 |
| CHEMBL4857350 | — | — | 1 | 6.95 |
| CHEMBL4879054 | — | — | 1 | 6.90 |
| CHEMBL4853342 | — | — | 1 | 6.83 |
| CHEMBL4873319 | — | — | 1 | 6.83 |
| CHEMBL4877940 | — | — | 1 | 6.82 |
| CHEMBL4856753 | — | — | 1 | 6.82 |
| CHEMBL4863980 | — | — | 1 | 6.79 |
| CHEMBL4877973 | — | — | 1 | 6.79 |
| CHEMBL4870716 | — | — | 1 | 6.78 |
| CHEMBL4878271 | — | — | 1 | 6.73 |
| CHEMBL4860828 | — | — | 1 | 6.71 |
| CHEMBL4870307 | — | — | 1 | 6.59 |
| CHEMBL4859348 | — | — | 1 | 6.57 |
| CHEMBL4857918 | — | — | 1 | 6.57 |
| CHEMBL4865735 | — | — | 1 | 6.57 |
| CHEMBL4876719 | — | — | 1 | 6.50 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 5.96 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4865907 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL4846866 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL4861193 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL4861311 | — | Ki | = | 13.4 | nM | 7.87 |
| CHEMBL4867978 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL4861643 | — | Ki | = | 15.8 | nM | 7.80 |
| CHEMBL4852663 | — | Ki | = | 93.7 | nM | 7.03 |
| CHEMBL4857350 | — | Ki | = | 112.6 | nM | 6.95 |
| CHEMBL4879054 | — | Ki | = | 125.3 | nM | 6.90 |
| CHEMBL4853342 | — | Ki | = | 148.7 | nM | 6.83 |
| CHEMBL4873319 | — | Ki | = | 147.2 | nM | 6.83 |
| CHEMBL4877940 | — | Ki | = | 151.2 | nM | 6.82 |
| CHEMBL4856753 | — | Ki | = | 153.2 | nM | 6.82 |
| CHEMBL4863980 | — | Ki | = | 163.4 | nM | 6.79 |
| CHEMBL4877973 | — | Ki | = | 163.7 | nM | 6.79 |
| CHEMBL4870716 | — | Ki | = | 166.3 | nM | 6.78 |
| CHEMBL4878271 | — | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL4860828 | — | Ki | = | 195.5 | nM | 6.71 |
| CHEMBL4870307 | — | Ki | = | 256.0 | nM | 6.59 |
| CHEMBL4859348 | — | Ki | = | 270.1 | nM | 6.57 |
| CHEMBL4857918 | — | Ki | = | 270.7 | nM | 6.57 |
| CHEMBL4865735 | — | Ki | = | 269.5 | nM | 6.57 |
| CHEMBL4876719 | — | Ki | = | 312.3 | nM | 6.50 |
| CHEMBL85 | RISPERIDONE | Ki | = | 1105.5 | nM | 5.96 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 2361.0 | nM | 5.63 |